Fairfield County Swim Coach Leads Team Beyond Pool Lanes

Posted on June 13, 2023June 26, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, nantucketTagged beneficiaries, cancer, nantucket cottage hospital, swim across america, swimming1 Comment

Marjorie Trifone
Swim Across America – Fairfield County
Hometown: Darien, Connecticut
10 years supporting Swim Across America
Age: 60

Marjorie (Marj) Trifone is no stranger to leading a strong team. She’s the head coach of the Darien High School Blue Wave Swim Team in her hometown, Darien, Connecticut.

At the Swim Across America – Fairfield County event, she also leads the team, Blue Wave Swim and Dive, whose members are students and alumni of the same high school team. Since 2016, the Blue Wave Swim and Dive team has raised over $27,500.

This year, Marj celebrates 10 years of supporting Swim Across America.

“Swimming is what we do, so I feel it is a wonderful event to be involved with for swimmers,” said Marj. “It shows them the other side of swimming not just for competition but for helping others.”

In addition to her ties to swimming, Marj has a personal connection to Swim Across America’s mission.

“I swim because my mother was a cancer survivor. She had non-Hodgkin’s lymphoma and underwent an experimental bone-marrow transplant in 1988 at Dana Farber Cancer Institute in Boston and then went on to live 21 more years!”

Swim Across America – Boston has supported clinical research at Dana Farber Cancer Institute since its first swim in 1996.

Marj and her family went through a challenging time as her mother bravely battled cancer. This experience is what gives Marj the drive and purpose to swim with the Blue Wave Swim and Dive for Swim Across America – Fairfield County – for family and friends still who have battled or are still struggling with the disease.

Swim Across America has raised $100 million since its inception in 1987 to support cancer research and clinical trials across the U.S. Please contact Jeni Howard at jhoward@jhowardpr.com for media inquiries.

TEAM HOPE MARKS 20th ANNIVERSARY OF MAKING WAVES TO FIGHT CANCER

Posted on June 12, 2023July 5, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, Top Fundraisers, UncategorizedTagged cancer research, fundraising, swim across americaLeave a comment

When you hear Mike Ford talk about TEAM HOPE, one word comes up over and over again – family. In fact, the word is a part of their “rallying cry.”

“We are swimmers, we are friends, we are families…We are TEAM HOPE!”

Mike was inspired to create TEAM HOPE in 2004 in honor of three close friends who were battling cancer. [Read the full history here.] This year marks TEAM HOPE’s 20^th year participating in Swim Across America events and the team has goal of raising $100,000. Since their first event, the team has raised a remarkable $1.4 million to support local beneficiaries.

“We’ve been together a long time. We’ve accomplished a lot over the years,” said Mike. “And, in so doing, we have become one big family.”

Joining TEAM HOPE becomes a bit of a family tradition for its ever-growing roster of members. Many of whom join because they have a loved one who is fighting cancer and they want to take action to help them in some way.

“If you look at a picture from our very first year, you’ll see some of the same faces in a picture from 2022. You’ll see even more faces because as everyone grows up and grows their families, they become members of TEAM HOPE.”

This “family history” is captured each year in the dedication board Mike has at the events.

“We all write down who we are swimming for, who we are honoring. The younger team members write down, ‘Grandpa’ or ‘Aunt Judy,’ and being a part of TEAM HOPE makes them feel like they are doing something important to help their family members. It makes them feel like they are making a difference.”

Over the years, members of TEAM HOPE have honored many, including Mike’s wife, Patti, who was diagnosed with cancer in 2005 and passed in 2016 after a courageous decade-long battle.

“Unfortunately, we aren’t unique. Everyone is fighting for someone. What makes us special is that we do it as a family.”

If you are moved to support TEAM HOPE to help them reach their $100,000 goal, you can donate here. Want to become part of the TEAM HOPE family? Join the team here.

Nantucket Nurse Recalls “Pivotal Time” in Administering Hospital’s First Immunotherapy Treatment

Posted on May 11, 2023July 24, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, nantucketTagged beneficiaries, cancer, nantucket cottage hospital, swim across america, swimming1 Comment

Gretchen Hull
Swim Across America – Nantucket
Hometown: Nantucket, MA
10 years supporting Swim Across America
Age: 49

Gretchen Hull is a triple threat supporter of Swim Across America. She’s an oncology nurse and Director of Infusion Services at Nantucket Cottage Hospital, passionate about health and personal wellness, and a swimmer!

In Gretchen’s own words, “the mission of Swim Across America – Nantucket – to support cancer services and research – aligns perfectly with my professional and personal goals.”

Gretchen has worked at Nantucket Cottage Hospital since 2002 and has been involved with Swim Across America for over a decade. It wasn’t until 2014, when Keytruda, of which Swim Across America assisted funding research, first became available at NCH, that she truly felt the impact and miracle of groundbreaking immunotherapy research.

“When Keytruda became available in 2014 there were only two chemotherapy certified nurses at NCH. I was the first nurse at my facility to administer Keytruda for its first indication. I knew it was a pivotal time in cancer care.”

Gretchen watched how the introduction of immune therapy changed the course of patient’s lives and trajectory of cancer diagnosis from terminal to chronic and curative at times. Moreover, how immunotherapy redefined how we view cancer and how cancer treatments have expanded across multiple types of cancer and benefited millions of people.

“I have to emphasize to nurses beginning their practice after the dawn of immunotherapy exactly how groundbreaking it is. I use the term “miracle” when referring to some outcomes.”

This year, Gretchen will swim the 4-mile course at Swim Across America – Nantucket.

What’s in Your SAA College Ambassador Member Kit?

Posted on May 10, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, Fundraising, UncategorizedLeave a comment

Swim Across America College Ambassadors are are part of the next generation of leaders. They support SAA by helping to engage the younger audience, promoting the Swim Across America mission and brand and encouraging their local communities’ involvement. Once you have been selected, we’ll reach out to congratulate you and send you an SAA College Ambassador’s Member Kit in the mail so you can show off your SAA spirit and be set up for success.

Here’s what you can expect in the mail:

1. Swim Across America Trucker Hat

Enjoy the exclusive Swim Across America College Ambassador’s Trucker Hat with our popular Wave logo. Perfect to throw on while enjoying time outside or walking to class.

2. Swim Across America Water Bottle

Stay hydrated and show your support with your new SAA branded water bottle.

3. Swim Across America Stickers & Buttons

Show your love on your car, laptop, backpack or jacket with the sticker and button we’ll be sending to help you spread the word about SAA!

4. Boost Your Fundraising Tips Sheet

Utilize these resources to help boost your fundraising and make a bigger impact!

Swim Across America Nantucket Honored to Extend Support to Mass General Cancer Center

Posted on April 27, 2023May 9, 2023 Posted in #SwimAcrossAmerica, beneficiaries, UncategorizedTagged beneficiaries, boston, nantucket, swim across americaLeave a comment

Mass General Cancer Center Joins the Swim’s Other Beneficiaries Nantucket Cottage Hospital Oncology Program and Palliative and Supportive Care of Nantucket.

NANTUCKET, Mass., April 26, 2023 – Swim Across America Nantucket is pleased to announce that Mass General Cancer Center will join Nantucket Cottage Hospital’s Oncology Program and Palliative and Supportive Care of Nantucket as a beneficiary of the Swim Across America Nantucket Open Water Swim event. The Swim Across America Nantucket open water swim has been held each Summer since 2012 and makes waves in the fight against cancer. This year’s event will be Saturday, July 22, 2023.

In addition to continuing to support the two local beneficiaries, Mass General will provide a research component to the list of services supported by Swim Across America Nantucket’s annual fundraising event. Dr. Bryan Choi, MD, PhD, is an attending neurosurgeon in the Department of Neurosurgery and the Stephen E. and Catherine Pappas Center for Neuro-Oncology at Mass General. He specializes in surgical care for patients with benign and malignant brain tumors. During his neurosurgery residency at the Massachusetts General Hospital, he pursued a postdoctoral fellowship in the laboratory of Dr. Marcela Maus, focused on developing CAR T-cell therapies for cancer. He also leads a research laboratory with the goal of developing the next generation of cell therapies and clinical trials in neuro-oncology.

“We are very honored to have the opportunity to support Dr. Choi in his work in CAR T-cell therapies,” said Jim Pignato, co-event director of Swim Across America Nantucket. “Adding a funding arm with a research component has been something we’ve been exploring. Teaming up with Dr. Choi and Mass General Cancer Care is a natural fit.”

“Dr. Choi’s work is groundbreaking and holds the potential to shift the paradigm of treatment for an otherwise devastating disease,” said Keith Erickson, director of development at Mass General Hospital.

“Our vision is to continue to help serve the Nantucket patient, from diagnosis through treatment, while also offering this very important research component, that will help all patients, not only those on Nantucket”, said Jill Roethke, co-event director of Swim Across America Nantucket.

This announcement comes on the heels of a banner 10th year for Swim Across America Nantucket, where more than $600,000 was raised for on-island cancer services and patient care in 2022.

Swim Across America was founded in 1987 with its first open water event in Long Island Sound. Since that time, the nonprofit organization has raised more than $100 million to fight cancer. In its 36 years of “making waves to fight cancer,” more than 100,000 swimmers and 150 Olympians have swum the circumference of the earth three times, uniting a movement to fight cancer that has created a groundswell of support spanning all generations. Today, more than 24 communities hold open water swims and charity pool swims each year, from Nantucket to under the Golden Gate Bridge, which support innovative cancer research, detection and patient programs.

Swim Across America’s funding of clinical trials for patients helped contribute to four FDA approved life-saving immunotherapy cancer treatments: Yervoy, Opdivo, Tecentriq and Keytruda. More than 60 scientific grants are funded each year and there are now ten dedicated Swim Across America Labs at major institutions including: Children’s Healthcare of Atlanta, John Hopkins Medicine Baltimore, Rush University Medical Center Chicago, Baylor Scott & White Charles A. Sammons Cancer Center in Dallas, Memorial Sloan Kettering Cancer Center New York, Infusion Center at Nantucket Cottage Hospital, Adolescent and Young Adult (AYA) Lounge at the Moffitt Cancer Center in Tampa, UCSF Benioff Children’s Hospital Oakland and San Francisco, Vanderbilt-Ingram Cancer Center in Nashville, and the Seattle Cancer Care Alliance.

To register to swim, volunteer or donate, please visit www.swimacrossamerica.org/nantucket. Instagram: @saanantucket Facebook: @saanantucket.Swim Across America Nantucket

About Swim Across America Nantucket:

Since 2012, Swim Across America Nantucket has raised more than $4 million for its beneficiaries: Nantucket Cottage Hospital and Palliative and Supportive Care of Nantucket. Each year Swim Across America Nantucket is proud to host more than 400 swimmers and volunteers, spectators and supporters, as well as Olympians near and far at the charity swim. This year’s swim will take place on Saturday July 22, 2023, at Jetties Beach on the island of Nantucket.

Breast Cancer Survivor Finds an Inspiring Way to Mark Two Milestones

Posted on April 14, 2023May 9, 2023 Posted in #DefeatCancer, #MakingWavesToFightCancer, #SwimAcrossAmerica, SAA Pride, wave makerTagged cancer, cancer research, fundraising, swim across america, swimming1 Comment

Michelle Deaton
Swim Across America – Tampa
Hometown: Wesley Chapel, Florida
2 years supporting Swim Across America
Age: 50

Michelle Deaton has a lot to celebrate this year and she wanted to mark the occasion by doing something she had never done before.

“I turned 50 in March and I’m five years cancer free! What better way to celebrate than with a two-mile swim with Wyatt!”

Last year, Michelle was a proud supporter of her son, Wyatt, who swam 2 miles in the 2022 Swim Across America – Tampa event. He raised nearly $6,000 in her honor. This year, they are training – and raising funds – together. What makes their swim even more special is that the event falls on Mother’s Day weekend.

“I’m so excited that my mom is training to swim with me,” said Wyatt. “She keeps telling me she will swim faster than me and beat me back to the beach. I’m just proud that she is cancer-free, just celebrated her 50th birthday on March 26, and is going to be my swim partner for Swim Across America.”

Michelle is cancer-free but that doesn’t mean she will stop supporting Swim Across America. She is likely one of our most enthusiastic participants!

“I just love, love, love Swim Across America and all it stands for,” said Michelle Deaton. “I talk about the work that Swim Across America supports everywhere I go and to everyone. I’m Swim Across America’s biggest fan. I’m thrilled to be able to swim and be a part of such a great event that impacts the lives of so many. I’m a true believer that when you put your mind to something, it might not be easy, but I’m blessed as I have gone through something tough like a cancer diagnosis, and it made me realize even more how miraculous our bodies really are.”

Finding New Meaning in Swim Across America Participation

Posted on April 5, 2023 Posted in #DefeatCancer, #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, event directors, UncategorizedTagged cancer, cancer research, fundraise, swim across america1 Comment

Susan McPherson

Swim Across America – Nashville

Hometown: Nashville, Tennessee

6 years with Swim Across America

Age: 79

Susan McPherson was no stranger to Swim Across America, but her contributions were always in honor of other family members and friends who had cancer diagnoses. After a shocking diagnosis in December 2020, the reason to support Swim Across America-Nashville now became much more personal for Susan.

“I went to the doctor because I was experiencing new-onset shortness of breath and found out I was anemic. After additional tests, the doctors told me they found a large tumor and multiple metastases in my abdomen and that I had stage four colon cancer.”

Susan’s particular genetic profile made her a candidate for immunotherapy. She began treatment at the Vanderbilt-Ingram Cancer Center, which is the beneficiary of the Swim Across America-Nashville Pool Swim.

“In fact, the type of immunotherapy I was given – Keytruda – was developed in the Swim Across America funded lab at the Johns Hopkins Cancer Center! What an incredibly serendipitous moment it was when I realized that the treatment that could help save my life was initially funded through Swim Across America fundraising events.”

Susan received treatment for two years and is now cancer-free. And her participation in this year’s Swim Across America – Nashville event is that much more poignant.

Susan’s daughter-in-law, Chris, is one of the event directors and coaches at the Ensworth Natatorium where the event is held. Her son, John, is a cardiologist at Vanderbilt University Medical Center. For the second year, Chris and John will swim with their team “Chris’ Cancer Crushers” in their endeavor to “make waves to fight cancer.”

Young Teen Recognizes Swim Across America’s Impact Within His Home

Posted on April 5, 2023June 26, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, Uncategorized, wave makerTagged cancer, cancer research, fundraise, swim across america1 Comment

Owen Johnson

Swim Across America – Charleston-Kiawah

Hometown: Mount Pleasant, South Carolina

3 years supporting Swim Across America

Age: 13

Owen Johnson is just 13 years old, and he already recognizes the impact funds raised at a Swim Across America charity swim have on patients and families.

“My dad, Brad Johnson, was diagnosed with stage four head and neck cancer before I was born. He survived because of new medicines discovered by cancer researchers, like the ones funded by Swim Across America.”

In 2020, the then-11-year-old swimmer had the idea to give his dad an unforgettable Christmas present. Instead of exchanging gifts, Owen set up a GoFundMe in honor of his dad’s fight against cancer. Owen raised over $2,000 and since then, has raised another $4,000 through his participation in the Swim Across America – Charleston-Kiawah events.

“I know Swim Across America gives money directly to researchers. My dad was the Event Director for Swim Across America – Charleston-Kiawah for a few years, and Swim Across America gives grants to cancer researchers at Hollings Cancer Center in Charleston where we live.”

This year, Owen and Brad will swim together at the Swim Across America – Charleston-Kiawah event on June 10. They are also celebrating a remarkable milestone. Brad has been cancer-free for 20 years.

“To celebrate 20 years and all the things my dad has accomplished since beating cancer – Ironman events, marathons, Triathlon World Championships, having a family – we are teaming up to raise $20,000 for the 2023 Swim Across America – Charleston-Kiawah event.”

“I hope that by raising money for Swim Across America, donations will help researchers get the funding they need to help more people like my dad.”

FDA Advisory Committee Supports Expanding Clinical Trial Swim Across America Has Helped Fund

Posted on February 21, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, Grant, Labs, UncategorizedLeave a comment

An immunotherapy clinical trial that Swim Across America provided grant funding has reached another milestone.

The Dr. Luis Diaz Lab at Memorial Sloan Kettering began receiving grants from Swim Across America in 2017. SAA grant funding allowed Dr. Diaz and his colleague, Dr. Andrea Cercek, to meet patients and conduct immunotherapy research. With SAA grant support, the lab opened a clinical trial and recruited 14 patients with advanced rectal cancer. The patients qualified through genetic testing and were treated with a single dose of immunotherapy. The patients didn’t require surgery, chemo, or radiation–which was remarkable as traditional treatments often have a negative emotional, physical, and financial effect on the quality of life for patients and their families.

Dr. Luis Diaz and Dr. Andrea Cercek

All 14 patients responded with no evidence of disease. This is believed to be the first time a clinical trial has shown a 100% response rate. Read the full story here.

Recently, the FDA Advisory Committee supported expanding the clinical trial to more patients based on the data from the trial.

The Diaz/Cercek lab has focused on rectal cancer where standard treatment options are surgery, chemotherapy, and radiation. While these treatments might save a patient, they have significant quality-of-life effects and often present the need for ongoing care.

This trial is genetically dependent and focused on advanced rectal cancer. Dr. Diaz and Dr. Cercek envision the immunotherapy being offered to patients with other cancer types who meet the genetic profile. Proceeds from the Long Island Sound and Nassau/Suffolk – Sound to Cove charity swims continue to help fund the ongoing research and clinical trial at Memorial Sloan Kettering.

Swim Across America has a proven track record of identifying and funding early-stage ideas of promise. Swim Across America grants have played a major role in clinically developing FDA-approved immunotherapy treatments ipilimumab (YERVOY), nivolumab (OPDIVO), pembrolizumab (KEYTRUDA), and atezolizumab (TECENTRIQ).

$4.2M granted to Seattle Cancer Care Alliance

Posted on June 20, 2022June 20, 2022 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, UncategorizedTagged cancer, fundraise, fundraising, Philanthropy, swim across america, swimmingLeave a comment

To date, Swim Across America has contributed close to $4.2 million for clinical research at Seattle Cancer Care Alliance and Fred Hutch. Starting in 2019, funds raised from the SAA-Seattle have gone to support breakthrough research by young investigators. In 2021, six grants were awarded to researchers focused on: lymphoma, sarcoma, breast, pancreatic, and urological cancer research. Below, the grant recipients share progress statements on their research over the last year.

Dr. Meghan Flanagan
Research focus: Breast cancer
Project title: Association of HSD3B1 (1245C) genotype with recurrence among post-menopausal women with estrogen receptor- positive, HER2- negative breast cancer
Background: Endocrine (antiestrogen) therapy reduces the risk of recurrence and improves mortality among women with hormone-receptor positive breast cancer. However, approximately one-quarter of women are inherently resistant or develop resistance to endocrine therapy. Ultimately, this research may allow us to identify women with innate endocrine resistance and develop novel therapeutics and treatment strategies.
Progress Statement: The SAA funds were used to evaluate whether an association exists between a mutation in a gene (HSD3B1, involved in hormone biosynthesis) and breast cancer outcomes. Using extensively collected clinical and pathologic data about patient demographics, tumor and treatment data and recurrence rates, we were able to show that women with two mutations in the HSD3B1 gene had higher rates of distant metastatic recurrence compared to those women who did not have this mutation. Future studies will be forthcoming to determine how this mutation may decrease the effectiveness of anti-estrogen medications that are used universally in post-menopausal ER+ breast cancer. This mutation is found in up to 15 percent of ER+ post-menopausal breast cancer patients, and if shown to decrease the effectiveness of anti-estrogen medications, there would be potential indications for alternative treatment strategies in these patients.

Dr. Sita Kugel
Research focus: Pancreatic Cancer
Project title: Exploring novel functions of HMGA2 in pancreatic cancer
Background: Pancreatic Ductal Adenocarcinoma (PDA) is an extremely lethal disease with a 5-year survival rate of less than 10%. Recent work has led to the discovery that PDA can be subdivided into two principal subtypes based on transcriptional signatures: classical and quasi-mesenchymal (QM). The QM PDA subtype is more aggressive and has the worst overall survival. Our laboratory has been focused on understanding of the mechanisms that drive each subtype in hopes of identifying therapeutic vulnerabilities that may be exploited in the clinic.
Progress Statement: Within an already challenging malignancy, there are transcriptional subtypes of pancreatic ductal adenocarcinoma that are especially lethal. Understanding what defines each subtype, as well as their susceptibilities and mechanisms of resistance, will help to identify new targeted therapies or combination therapies and lead to more treatment options for this devastating disease.

Dr. Jonathan Sham
Research focus: Pancreatic Cancer
Project title: Novel Drug- eluting Biopolymer to Reduce Pancreatic Fistula and Improve Outcomes After Pancreatic Surgery
Background: Pancreatectomy is the mainstay of any potentially curative treatment regimen for pancreatic cancer. Despite an overall improvement in the safety of pancreatic surgery over the past several decades, the morbidity of pancreatectomy remains exceedingly high. The most significant complication after pancreatic surgery is postoperative pancreatic fistula (POPF), which occurs in up to 60% of cases. The use of a biopolymer, poly(Nisopropylacrylamide) (PNIPAM), is an innovative method to prevent leakage of pancreatic juice from the cut surface of the gland, while the suspended octreotide- eluting microspheres will simultaneously reduce baseline pancreatic fluid secretion. This novel dual-action approach will be tested in a validated rat model of POPF with the goal of rapid clinical translation and patient benefit.
Progress Statement: Swim Across America is advancing our work to improve outcomes after pancreatic surgery. Their support is enabling a trailblazing collaboration between surgeons and bioengineers to develop novel ways to stop leaks after pancreas surgery and make patients live happier, healthier and longer lives. Polymer synthesis is moving forward, and two teams are working on creating and testing polymers with different characteristics for use in our animal experiments.

Dr. Jordan Gauthier
Research focus: CAR T-cell therapy
Project title: Factors associated with failure of CD19 CAR T cells in diffuse large B cell lymphoma
Background: We are investigating two factors potentially critical to failure of CD19 CAR T-cell therapy for DLBCL: a) T cell dysfunction, impeding the generation of functional CAR T cells during manufacturing; b) the suppressive tumor microenvironment (TME). Our studies will better characterize T cell dysfunction and the TME as core mechanisms of failure of CD19 CAR T cells and identify potential targets to improve outcomes of CAR T-cell therapy for DLBCL.
Progress Statement: The Swim Across America grant allowed us to explore the two following aims.
Aim 1: To determine whether exhausted T cells are associated with treatment failure after CAR T-cell therapy for diffuse large B-cell lymphoma (DLBCL). We analyzed blood samples from 34 DLBCL patients treated on a clinical trial of CAR T-cell therapy. While we did not confirm an association between exhausted T cells and treatment failure, we found that a higher proportion of terminally differentiated T cells may have an adverse impact on the outcomes of CAR T-cell therapy.
Aim 2: To determine if an exhausted gene signature in T cells from lymphoma tumors is associated with treatment failure, we analyzed pre-treatment tumor biopsies obtained from 17 patients receiving CAR T-cell therapy. In biopsies from patients in complete response after CAR T-cell therapy, we found that T cell-associated genes were overexpressed compared to patients not in complete response after treatment. This suggests that tumors more permissive to T cell infiltration might respond better to CAR T-cell therapy. So far, we have not confirmed that an exhausted gene signature is associated with treatment failure. The SAA grant has been used to design and optimize novel assays that will allow us to further address this aim in the future.

Dr. John Lee
Research focus: Sarcoma
Project title: Development of STEAP1 chimeric antigen receptor T-cell therapy for Ewing sarcoma
Background: Ewing sarcoma (ES) is a soft tissue/bone cancer with 200 newly diagnosed adolescents/young adults per year in the United States. Patients with metastatic dissemination face a very grim prognosis as available treatments are unable to eradicate the disease. New therapeutic approaches are needed. If successful, these studies will help lay the groundwork for the development and clinical translation of a first-in-field STEAP1 CAR T-cell immunotherapy for ES.
Progress Statement: We applied the Swim Across America grant to evaluate whether a novel chimeric antigen receptor (CAR) T cell therapy targeting the protein STEAP1 could be an effective strategy to treat Ewing sarcoma. Our results indicate that human Ewing sarcoma tumor models commonly express STEAP1 and are susceptible to killing by STEAP1 CAR T cells. In related studies, we have also determined that STEAP1 CAR T cell therapy appears safe in a novel mouse model that we engineered to express human STEAP1. Together, these findings provide the rational to translate STEAP1 CAR T cell therapy into clinical trials for Ewing sarcoma in the near future.

Dr. Adam Gadzinski
Research focus: Urological cancer
Project title: Interstate Telehealth to improve access to urological cancer care among rural patients.
Background: Timely access to urological cancer care is challenging for rural patients who often travel great distances to tertiary centers. This is particularly true for patients residing in the WWAMI (Washington, Wyoming, Alaska, Montana, Idaho) region. We hypothesize that Telehealth will provide similar patient satisfaction, reduced costs, and earlier time to treatment. We further hypothesize that implementation of the interstate Telehealth program will decrease referral to visit time and increase clinical efficiency. Lastly, we hypothesize that providing Telehealth appointments will increase the frequency of referrals from rural areas. We anticipate that implementation of our interstate Telehealth program will improve access to urological cancer care for rural and underserved patients throughout the WWAMI region.
Progress Statement: Our SAA grant has been used to support our telemedicine research efforts to assess the quality of telemedicine visits for cancer patients from rural areas and the Pacific Northwest states. We have demonstrated that telemedicine visits save cancer patients and their families a significant amount of time and money that would have been spent traveling to doctor appointments. We also found that patients are very satisfied with receiving cancer care remotely via telemedicine, especially during the COVID-19 pandemic.