Read or watch local stories featuring the Swim Across America-Long Island Sound community to learn about their impact. Learn more about the event and beneficiaries, Memorial Sloan Kettering Cancer Center, Columbia University Cancer Center, Cancer Support Team, and Weill Cornell Medical Center, at swimacrossamerica.org/long_island.
Read or watch local stories featuring the Swim Across America-Nantucket community to learn about their impact. Learn more about the event and beneficiaries, Nantucket Cottage Hospital, Palliative and Supportive Care of Nantucket, and Mass General Cancer Center, at swimacrossamerica.org/nantucket.
Almost a year-and-a-half after sadly losing Gina Mannix Wente to breast cancer, who was just 32-years-old and a beloved wife, mother, daughter and sister, more than 50 of her relatives and friends are suiting up again to make a big splash with “Team Gina” at the 33rd annual Swim Across America – Long Island Sound open water swim on Saturday, July 26, held on the shores of Long Island Sound in Larchmont, New York.
Gina Mannix Wente
The team has hit the ground running and is already one of the top fundraising teams, raising $33,255 to date for the July charity swim. For Team Gina, diving back into the water isn’t just a tribute – it’s a way to keep Gina’s competitive spirit and generosity alive – all while fueling cancer research that could help others battle this terrible disease.
Gina grew up swimming at the Larchmont Shore Club, captained undefeated squads at Ursuline and the College of the Holy Cross, and later coached for the New York Athletic Club. She balanced that passion with a finance career that took her to GE Capital and Ferrara Candy. In 2021 she married Dave Wente. Their daughter, McKenzie, arrived in 2022, and their son, David Charles, was delivered early at just 29 weeks on February 1, 2024, weeks after Gina’s sudden cancer diagnosis. Gina sadly passed away on February 26, 2024, just 3-1/2 weeks after welcoming her son.
Gina and her daughter, McKenzie
“Last summer’s swim, was as you can imagine, raw and emotional for all of us after losing Gina so suddenly,” noted Gina’s mother, Mary Mannix. “However, being all together at the swim and doing something that Gina loved was also very healing. We are coming back this year stronger and more energized than ever before. Every dollar we raise honors her love of the sport of swimming and helps fund the breakthroughs that can possibly help save other lives.”
“Cancer knows no boundaries,” noted Jean Fufidio, event director for SAA-Long Island Sound. “It impacts adults, young adults and children. Diagnoses of young adults globally have risen by 79%. But here’s how Swim Across America Long Island Sound is making a positive impact. A recent Time Magazine story, ‘The Race to Explain Why More Young Adults are Getting Cancer’ mentioned the ground-breaking, rectal clinical trials done by one of our very own fellow doctors, with a 100% response rate. A subsequent trial that was expanded to other gastrointestinal MMRd type cancers and published in The New England Journal of Medicinein April showed an astounding 80% success rate with immunotherapy alone – no surgery, chemotherapy or radiation. That is making an impact.”
Members of Team Gina swam at the 2024 SAA-Long Island Sound open water swim
Proceeds from SAA-Long Island Sound benefit Swim Across America’s local beneficiaries: Memorial Sloan Kettering Cancer Center, Columbia University Medical Center, Cancer Support Team and Weill Cornell Medicine. Registration, volunteer sign-ups and donations are open at swimacrossamerica.org/longislandsound.
Now in its 33rd year, SAA-Long Island Sound open water and pool swims have contributed nearly $30 million towards cancer research, resulting in FDA approved immunotherapy treatments of Keytruda, Opdivo and Yervoy. What’s more is the money raised locally stays local, providing cancer care and research grants to The Cancer Support Team, a Westchester-based home care program offering free services to patients and their families; to New York Presbyterian Children’s Hospital Pediatric Oncology Lab; to Memorial Sloan-Kettering Research Laboratories of Dr. Diaz and Dr. Kung Kids Department of Pediatrics;and to Weill Cornell Medicine Research Laboratory of Dr. Wolchok and Dr. Merghoub.
Swimming a one-mile open water swim is challenging, but swimming a one-mile open water swim with cancer is nothing short of remarkable. David Lemley is one of those remarkable people.
David, with his wife, Janie, swam at the 2024 SAA-Seattle open water swim, while fighting plasma cell leukemia.
David, 65, first participated in Swim Across America – Seattle in 2021 supporting his wife, Janie’s, team “InMemory”, named for the loved ones she lost to cancer. Over the years, their team has raised more than $8,000. It wasn’t until this year that David’s understanding of cancer became very personal.
“Last year, I really struggled to finish the swim,” said David. “The reason being, unbeknownst to us at the time, that I was fighting plasma cell leukemia, a very rare and aggressive form of blood cancer.”
This may seem like a rare occurrence, but often Swim Across America participants become fighters of their own cancer battles, giving their involvement a new meaning and a sense of urgency.
“Swim Across America is extremely important to help fund urgent and necessary research in order to help more people become cancer survivors. SAA gives hope to those, like myself, who are fighting the cancer battle right now,” shared David.
David’s stem cells were harvested at Fred Hutch Cancer Center, the beneficiary of the SAA-Seattle swim.
Swim Across America’s guiding principle is that money raised local stays in each community. In Seattle, all proceeds from community events support immunotherapy clinical trials and cancer research at Fred Hutch Cancer Center.
Participants that fundraise know that the funds they raise will support their community to help people they may know, or in David’s case, his own treatment. Despite being a fundraiser year after year, David never imagined he would become a direct recipient of the treatment himself and hundreds of other swimmers help support.
After receiving his diagnosis in November 2024, David was thrown into a new world of hospital visits and chemotherapy treatment. As he prepared for his double stem cell transplant at the VA Medical Center near his hometown, David had his first visit to Fred Hutch Cancer Center (FHCC).
“I was at the VA for 13 days and then headed to Fred Hutch for the incredible procedure of Apheresis, where they harvest 17 million of my stem cells. Janie and I wore our Swim Across America t-shirts to commemorate this very special day,” said David.
David and Janie proudly wore their Swim Across America shirts during David’s stay at FHCC.
“On Monday, May 5th, I celebrated my new ‘birthday’ with the first transplant of approx. 8.5 million of my own stem cells,” said David.
After 16 days in the hospital following the procedure, David was released to go home to rest and recover before his second stem cell procedure on June 9.
For the Lemley family, participating in this year’s SAA-Seattle has a deeper meaning.
“Now, more than ever, we are committed to raising money for our amazing Fred Hutch Cancer Research Center!” said David.
If you’re inspired to support David and Team InMemory, give here.
Doug Bosley has completed some of the most challenging marathon swims in the world, including the cross-continental Hellespont Dardanelles swim, the Maui Channel swim, the Boston Harbor Swim and the St. Croix Reef swim. He has also participated in nearly 30 Swim Across America swims, including Boston and San Francisco.
While those swims were intense, Doug is now facing one of his toughest battles yet: beating acral lentiginous melanoma, a rare form of skin cancer that has sadly spread and metastasized. Despite his diagnosis, Doug’s sense of humor remains intact. He colors his story with anecdotes, punchlines and heartfelt emotion.
“In March 2024, I discovered a very tiny dot on my heel; it was no bigger than an eraser head. So I got it checked out and was diagnosed with a rare form of skin cancer. Not exactly what you want to hear,” Doug shared lightheartedly.
Doug Bosley (back row, center) and Team Festivus at the 2023 Swim Across America – Boston open water swim.
Doug began treatment at Mass General Cancer Center, one of the beneficiaries of the Swim Across America – Boston community swim. The swim also supports Dana-Farber Cancer Institute. Unfortunately, the cancer has quickly progressed and has spread to his liver and brain.
After initial treatments were unsuccessful, Doug was put on BRAF therapy, a combination of medicines that can shrink or slow the growth of metastatic melanoma in those whose tumors have a BRAF mutation. The treatment helped with his liver and lymph nodes but not his brain due to the blood-brain barrier.
He is currently being treated with two immunotherapy medicines – Yervoy and Opdivo – both which received early-stage grant funding from Swim Across America and are FDA approved for treating several different types of cancer.
“I’m doing ok, but the effects of my treatments are taking a toll,” said Doug. “My skin is incredibly sensitive, my feet are swollen to the point where it’s difficult to walk around, my head is foggy, and I have no saliva. But I’m sitting here, employed and engaged to be married – so that’s a good thing.”
Yes, Doug is engaged! After Doug was diagnosed, he proposed to his longtime girlfriend, Laura Lipcsei. The couple splits their time between their house in Somerville, Massachusetts, and the lake cabin they built together in Ontario, Canada.
“I said to Laura, ‘Now is the time to get married because I don’t know where I’ll be in a year,” joked Doug.
In addition to being thankful for Laura, Doug expresses his appreciation for his Swim Across America family, who have supported him through this journey.
Doug, back row center, participated in the 2009 Swim Across America – Boston Harbor swim.
“My Swim Across America family in Boston means everything to me. We started doing the swims as something fun to do together. Somewhere along the way, it became something more emotional. We’d swim, have fun, have a good cry, then come back the next year. Thirty years later and we’re still here,” shared Doug.
One member of Doug’s SAA-Boston swim group has helped him tremendously. Rick Osterberg, who himself is a cancer survivor and also received an immunotherapy pioneered with funding provided by Swim Across America, is Doug’s “cancer coach” and they swim together on Team Festivus.
“So between my wedding, turning 62 and the August 9 SAA-Boston swim, I’ve got a lot to look forward to this summer! I really want to be up there sharing my story with everyone who has supported me this past year.” said Doug.
If you’re inspired to support Doug and Team Festivus, give here.
Read or watch local stories featuring the Swim Across America – Tampa community to learn about their impact. Learn more about the event and beneficiary, Johns Hopkins All Children’s Hospital, at swimacrossamerica.org/tampa.
The Promising Study Found that 80% of Patients with Mismatch Repair-Deficient (MMRd) Solid Tumors Treated with Immunotherapy Avoided Surgery
The New England Journal of Medicinepublished a paper on April 27, 2025, that presents exciting new results from a clinical trial led by Memorial Sloan Kettering Cancer Center (MSK) gastrointestinal oncologists Andrea Cercek, MD, and Luis Diaz Jr., MD, that demonstrates how immunotherapy alone can help patients with MMRd cancers avoid surgery and preserve their quality of life. The results, presented simultaneously at the 2025 American Association of Cancer Research (AACR) Annual Meeting, showed that 80% of patients with several types of cancer treated with immunotherapy did not require surgery, radiation, or chemotherapy after six months of treatment with immunotherapy alone. Swim Across America awarded grants for the early-stage research and continues to award grants for the ongoing clinical trial.
Andrea Cercek, M.D., gastrointestinal oncologist and co-director of the Center for Young Onset Colorectal and Gastrointestinal Cancer at Memorial Sloan Kettering Cancer Center
Mismatch repair deficiency (MMRd) in cancer refers to a situation where tumor cells have defective mismatch repair (MMR) proteins, essential for correcting DNA errors during cell replication. This deficiency leads to the accumulation of mutations, including microsatellite instability (MSI), making tumors more prone to be recognized by the immune system. MMRd status is a significant factor in cancer treatment, particularly for immunotherapy, as it can predict response to immune checkpoint inhibitors.
The standard of care for many cancers that have this specific MMRd genetic mutation has been surgery, radiation, and chemotherapy. Still, the patients who responded positively to this clinical trial did not require surgery to remove an organ and did not experience chemotherapy or radiation, which improved their quality of life. This trial is the first time that immunotherapy has been shown to replace surgery for a variety of solid tumors.
“This study shows that immunotherapy can replace surgery, radiation and chemotherapy for mismatch repair-deficient solid tumors, which could help patients preserve their organs and avoid the harsh side effects of chemo and radiation,” said Andrea Cercek, M.D., gastrointestinal oncologist and co-director of the Center for Young Onset Colorectal and Gastrointestinal Cancer at Memorial Sloan Kettering Cancer Center. “Preserving a patient’s quality of life, while also successfully achieving positive results in eliminating their cancer, is the best possible outcome. They can return to their daily routines and maintain their independence.”
Luis Diaz, M.D., gastrointestinal oncologist and Head of the Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center
This phase 2 trial is an extension of a groundbreaking study, also funded in part by Swim Across America, in which all rectal cancer patients treated with the immunotherapy dostarlimab experienced a complete clinical response, meaning their tumors disappeared. This was the first time ever that a clinical trial had a 100% positive response rate.
The updated trial included 103 patients with stage 1-3 cancer; 49 with rectal cancer; and 54 with non-rectal cancers, including gastroesophageal, hepatobiliary, colon, genitourinary, and gynecologic. Drs. Cercek and Diaz noted that the 80% response rate in this expanded clinical trial is very exciting for these types of cancer.
“Grants provided by Swim Across America were critical to our initial study and advancing this trial to phase 2,” said Luis Diaz, M.D., gastrointestinal oncologist and Head of the Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center.
Founded in 1987, Swim Across America has raised more than $100 million to fight cancer. In its 38 years of making waves, thousands of volunteers and Olympians have swum the circumference of the earth three times uniting a movement to fight cancer that has created a groundswell of support spanning all generations. Today, more than 24 communities across the U.S. hold charity swims each year, which support innovative cancer research, detection, and patient programs.
Drs. Andrea Cercek and Luis Diaz spoke at the 2024 Swim Across America – Long Island Sound open water swim
Swim Across America’s funding of clinical trials on a national level has helped contribute to four FDA-approved life-saving immunotherapy cancer treatments: Yervoy, Opdivo, Tecentriq, and Keytruda. Swim Across America awards grant to more than 60 projects each year and there are ten named Swim Across America Labs at major institutions.
In addition to Swim Across America grants, this trial received funding from the National Institutes of Health, National Cancer Institute, Haystack Oncology, and Stand Up To Cancer. MSK also acknowledges support from GSK, whose PD-1 blockade Jemperli (dostarlimab), represents a promising advancement in the treatment of patients.
For more information and to inquire about eligibility for this clinical trial, talk to your oncologist or call MSK at 646-888-4189. You may also reach to info@swimacrossamerica.org and we will help guide you.
Choi’s next generation CAR-T therapy, funded in part by SAA-Boston and SAA-Nantucket, has shown “dramatic and rapid” regression of glioblastoma
With early funding from Swim Across America – Boston and Swim Across America – Nantucket, Dr. Bryan Choi’s research on tandem CAR T-cell therapy for ependymoma was approved for a Phase I trial. The first human patient was infused at the end of April 2023. The results of the first human trials, as described in 2024 by the New England Journal of Medicine, showed “dramatic and rapid” regression of glioblastoma.
In an exclusive briefing to Swim Across America participants, Dr. Bryan Choi, a neurosurgeon and neuro-oncologist at Massachusetts General Cancer Center, delivered an update on his research path.
From left, brain tumors, marked by red and green arrows, disappear a day after CAR-T immunotherapy treatment. From CNN.
The Swim Across America lab visit included not only highlights from on the ongoing Phase I trial, but also a few first-hand stories about the life-changing impacts of the new CAR-T cell therapy for one of the patients, who has chosen to share his story publicly.
Tom Fraser (Patient #2) has shared his story publicly with news outlets that include CNN and New York Magazine.
Tom Fraser, 72, (center, in the blue shirt) was treated with a single infusion of CAR-T cells. Two days later, an MRI showed a decrease in the tumor’s size by 18.5 percent. By day 69, the tumor had decreased by 60.7 percent, and the response was sustained for over 6 months. From The Harvard Gazette.
CAR T-cell therapy, a type of gene therapy that engineers a patient’s own T-cells (a type of white blood cells) to identify and attack cancer cells by way of their antigen markers, has shown promise in the treatment of blood cancers. The research team created dual antigen-targeting tandem CAR T (TanCART) cells to target heterogeneous solid tumors. Dr. Choi’s research shows that this type of therapy can also be manipulated to treat solid tumors like ependymoma.
At the suggestion of Dr. Howard Weinstein, Unit Chief of Pediatric Hematology/Oncology at Mass General for Children and long-time Swim Across America partner, Dr. Choi applied for a Swim Across America research grant through the internal competitive bid program at Mass General for Children.
Dr. Choi recruiting the next generation of researchers, like SAA – Nantucket supporter, Braden Hussey.
Without the Swim Across America grant, Dr. Choi said, his research likely would have remained unfunded, and neither the FDA approval nor the Phase I Study approval, which is funded by industry investors, would have been possible.
Janel Jorgensen McArdle, Chief Operating Officer of Swim Across America, pointed out that Dr. Choi’s research falls in the “sweet spot” of the high risk, high reward research that Swim Across America is pursuing.
“This promising research aligned perfectly with the opportunities that Swim Across America seeks to support,” said McArdle. “We are so excited that SAA funding could help accelerate it to patient trials – and are thrilled to see the benefits to patients!”
Dr. Choi explained CAR-T cell therapy to the Swim Across America group on April 4, 2025.
After his highly informative presentation, Dr. Choi gave the Swim Across America group a private tour of his lab spaces, which were in the finishing stages of build-out when they toured two years ago.
The group also got to visit the Ether Dome at Mass General, the surgical amphitheater where, in 1846, the first public surgery with anesthesia was performed.
It was an exciting visit for Swim Across America news and for all of the Swim Across America – Boston and Nantucket supporters who were present!
Swim Across America lab visit participants, pictured with Dr. Choi in the Ether Dome at Mass General, site of the first use of anesthesia in public surgery.
Revolutionary CRISPR Gene Editing and Other Cell and Gene Therapy Editing Takes Center Stage in Finding Ways to Effectively Treat Cancer
Swim Across America, the nonprofit funding innovative clinical trials and patient-centered programs for cancer,is proud to announce the award of two $450,000 grants to two of its beneficiaries, Alliance for Cancer Gene Therapy(ACGT) and Dana-Farber Cancer Institute, to support the work of novel gene and base editing techniques used in advanced cancer research, including targeted therapies, immunotherapies and cellular therapies. The two-year grants will specifically support the work of scientific investigators Joseph Fraietta, PhD, at the University of Pennsylvania through ACGT, and Pietro Genovese, PhD, at Dana-Farber Cancer Institute, for their work in groundbreaking cell and gene therapy cancer research. This financial support paves the way for more effective therapies across many cancer types including solid tumors, offering potential new hope for patients with hard to treat cancer types or limited treatment options.
“Gene editing, including CRISPR, are some of the most promising frontiers in cancer research allowing for advances in targeted therapies, immunotherapies, CAR-T cell therapy and early/minimal residual disease detection, diagnostics and cancer vaccines,” said Rob Butcher, CEO of Swim Across America. “These grants to Dr. Fraietta through ACGT, and Dr. Genovese at Dana-Farber, will help accelerate the advancement of potential gene-edited cancer treatments that could transform how we treat patients and their quality of life. Just as our previous funding has helped develop immunotherapy treatments that are saving lives today, we believe these pointed investments will help accelerate the next generation of cancer breakthroughs.”
Joseph Fraietta, PhD
Joseph Fraietta, PhD, through Swim Across America–Fairfield County beneficiary Alliance for Cancer Gene Therapy, is developing an innovative “off-the-shelf” cell therapy for aggressive cancers. His research uses a precise gene-editing tool called a “base editor” to create more effective CAR T cells that can target cancers with KRAS mutations, found in 20-25% of all cancers including lung, colon and pancreatic cancer. His team is also developing “micropharmacies” – immune cells engineered to release powerful cancer-fighting signals directly at tumor sites while minimizing side effects.
Pietro Genovese, PhD
Pietro Genovese, PhD, at Dana-Farber, is taking a revolutionary approach to treating acute myeloid leukemia (AML). Rather than targeting cancer cells directly, his team is creating “stealth” healthy blood cells engineered to survive cancer treatments while allowing the selective elimination of cancer cells. This innovative strategy could provide less toxic treatment options for AML and other blood cancers where traditional therapies often harm healthy cells along with cancerous ones.
“With the current funding landscape and resources potentially constrained, nonprofit organizations play a vital role in ensuring innovative cancer research moves forward,” said Evan Vosburgh, MD, Research and Grants committee chair for Swim Across America. “These targeted grants support precisely the kind of high-risk, high-reward research that could revolutionize cancer treatment, but might otherwise go unfunded. By supporting early-stage research in cell and gene therapy, we’re helping bridge critical funding gaps and accelerating the development of potentially life-saving treatments.”
Swim Across America has raised more than $100 million for cancer research since its founding in 1987 and has a strong track record of funding transformative research, including clinical trials that led to FDA-approved immunotherapy medicines Keytruda, Opdivo, Yervoy and Tecentriq. The organization was also a grant funder of Memorial Sloan Kettering’s landmark clinical trial that achieved a 100% success rate treating advanced rectal cancer patients with dostarlimab.
About Swim Across America Swim Across America hosts open water and pool swims in numerous communities nationwide, from Nantucket to under San Francisco’s Golden Gate Bridge. More than 150 Olympians support the organization, including Michael Phelps, Kate Douglass, Missy Franklin and Ryan Lochte. The organization supports more than 60 cancer research projects annually and has ten named Swim Across America Labs at major institutions nationwide. To learn more visit swimacrossamerica.org or follow on social media @SwimAcrossAmerica on Facebook and @SAASwim on Instagram.
Francesca “Frankie” Grieco-Routh is a kind and caring 13-year-old who loves making art, reading, listening to music, and cheering on her two younger sisters, Emmersan and Augustine. She’s also a leukemia survivor celebrating 10 years of being minimal residual disease (MRD) negative—meaning no cancer cells can be detected in her blood.
“Frankie is so full of life, and her personality is most like Buddy from the movie Elf. She’s full of joy and laughter and wants everyone around her to be happy and comforted,” shared her mother, Giselle. “She loves painting, spending time with family, and being with her service dog, Luna. She’s our warrior.”
This year, the Grieco-Routh family will attend Swim Across America – Tampa Bay on May 10, supported by Emmersan’s team, Team BEST. Emmersan, or Emmie, is an 11-year-old competitive swimmer with St. Petersburg Aquatics and will be a rookie swimmer at this year’s event. She will be joined by friends and teammates to honor her sister Frankie.
The Grieco-Routh family
“Whatever we do, we do it as a family, and we go all in,” said Giselle. “So when Coach Brackin met Emmie and heard our family’s story, she graciously offered to have their team fundraise in Frankie’s honor. Emmie is excited to swim, and doing it for her sister makes it even more special.”
Giselle and her husband, Ryan, moved Frankie, Emmie, and Augustine (August) from Southern California to St. Petersburg, Florida, to be closer to family and ensure Frankie could continue her long-term maintenance care at Johns Hopkins All Children’s Hospital (JHACH). Swim Across America – Tampa Bay raises funds for immunotherapy research at JHACH and has contributed over $2 million to its beneficiaries since 2012.
“The support we’ve received since moving to St. Petersburg has been incredible—not just from the swimming community, but from the amazing team at JHACH. The care Frankie has received there is unmatched,” said Giselle.
Frankie was just three years old when she was diagnosed with leukemia. After months of unexplained illness and several misdiagnoses, Giselle pushed doctors to order a complete series of tests. That’s when they received the devastating news no family wants to hear.
Frankie saw her first movie at the hospital theater while receiving treatment for leukemia.
“The doctor called me and told me to get Frankie to the hospital immediately. Her white blood cell count was extremely high and her body was shutting down. She was rushed into treatment and spent two weeks in the hospital, receiving intense chemotherapy daily and undergoing countless procedures, including weekly spinal taps,” said Giselle.
At the time, Giselle and Ryan had Frankie, 10-month old Emmie, and just found out she was pregnant with their third daughter.
“To say it was overwhelming would be an understatement!” joked Giselle.
Despite everything, Frankie amazed everyone with her strength. Because her immune system was severely compromised, she couldn’t leave her hospital room, but that didn’t stop her from keeping herself entertained with art and movies.
“She would even make art out of her food—stacking bagels and spreading jelly on trays! She was so strong despite being in so much pain,” Giselle shared.
Frankie’s strength extended beyond her own battle—she found ways to comfort other families fighting similar struggles. Even if she couldn’t leave her room, she still sent love and support from afar.
“Every time we heard another family having a tough time—a child crying or a mother sobbing through a broken heart—we’d send them love through our ‘magic fingers,’” Giselle said, as she and Frankie wiggled their fingers in the air.
August, Emmie and Frankie Grieco-Routh
As Emmie takes on open water swimming with her team, Frankie, Giselle, Ryan, and August will be on the beach cheering her on. No matter the challenge, they face it together.
“Whether it’s swimming, gymnastics, or leukemia, we are each other’s biggest cheerleaders and support system. Seeing our daughters support each other through thick and thin makes us incredibly proud.”
If you are inspired to support Frankie, Emmie and Team BEST, give here.
Swim Across America 