Swim Across America Nantucket Honored to Extend Support to Mass General Cancer Center

Posted on April 27, 2023May 9, 2023 Posted in #SwimAcrossAmerica, beneficiaries, UncategorizedTagged beneficiaries, boston, nantucket, swim across americaLeave a comment

Mass General Cancer Center Joins the Swim’s Other Beneficiaries Nantucket Cottage Hospital Oncology Program and Palliative and Supportive Care of Nantucket.

NANTUCKET, Mass., April 26, 2023 – Swim Across America Nantucket is pleased to announce that Mass General Cancer Center will join Nantucket Cottage Hospital’s Oncology Program and Palliative and Supportive Care of Nantucket as a beneficiary of the Swim Across America Nantucket Open Water Swim event. The Swim Across America Nantucket open water swim has been held each Summer since 2012 and makes waves in the fight against cancer. This year’s event will be Saturday, July 22, 2023.

In addition to continuing to support the two local beneficiaries, Mass General will provide a research component to the list of services supported by Swim Across America Nantucket’s annual fundraising event. Dr. Bryan Choi, MD, PhD, is an attending neurosurgeon in the Department of Neurosurgery and the Stephen E. and Catherine Pappas Center for Neuro-Oncology at Mass General. He specializes in surgical care for patients with benign and malignant brain tumors. During his neurosurgery residency at the Massachusetts General Hospital, he pursued a postdoctoral fellowship in the laboratory of Dr. Marcela Maus, focused on developing CAR T-cell therapies for cancer. He also leads a research laboratory with the goal of developing the next generation of cell therapies and clinical trials in neuro-oncology.

“We are very honored to have the opportunity to support Dr. Choi in his work in CAR T-cell therapies,” said Jim Pignato, co-event director of Swim Across America Nantucket. “Adding a funding arm with a research component has been something we’ve been exploring. Teaming up with Dr. Choi and Mass General Cancer Care is a natural fit.”

“Dr. Choi’s work is groundbreaking and holds the potential to shift the paradigm of treatment for an otherwise devastating disease,” said Keith Erickson, director of development at Mass General Hospital.

“Our vision is to continue to help serve the Nantucket patient, from diagnosis through treatment, while also offering this very important research component, that will help all patients, not only those on Nantucket”, said Jill Roethke, co-event director of Swim Across America Nantucket.

This announcement comes on the heels of a banner 10th year for Swim Across America Nantucket, where more than $600,000 was raised for on-island cancer services and patient care in 2022.

Swim Across America was founded in 1987 with its first open water event in Long Island Sound. Since that time, the nonprofit organization has raised more than $100 million to fight cancer. In its 36 years of “making waves to fight cancer,” more than 100,000 swimmers and 150 Olympians have swum the circumference of the earth three times, uniting a movement to fight cancer that has created a groundswell of support spanning all generations. Today, more than 24 communities hold open water swims and charity pool swims each year, from Nantucket to under the Golden Gate Bridge, which support innovative cancer research, detection and patient programs.

Swim Across America’s funding of clinical trials for patients helped contribute to four FDA approved life-saving immunotherapy cancer treatments: Yervoy, Opdivo, Tecentriq and Keytruda. More than 60 scientific grants are funded each year and there are now ten dedicated Swim Across America Labs at major institutions including: Children’s Healthcare of Atlanta, John Hopkins Medicine Baltimore, Rush University Medical Center Chicago, Baylor Scott & White Charles A. Sammons Cancer Center in Dallas, Memorial Sloan Kettering Cancer Center New York, Infusion Center at Nantucket Cottage Hospital, Adolescent and Young Adult (AYA) Lounge at the Moffitt Cancer Center in Tampa, UCSF Benioff Children’s Hospital Oakland and San Francisco, Vanderbilt-Ingram Cancer Center in Nashville, and the Seattle Cancer Care Alliance.

To register to swim, volunteer or donate, please visit www.swimacrossamerica.org/nantucket. Instagram: @saanantucket Facebook: @saanantucket.Swim Across America Nantucket

About Swim Across America Nantucket:

Since 2012, Swim Across America Nantucket has raised more than $4 million for its beneficiaries: Nantucket Cottage Hospital and Palliative and Supportive Care of Nantucket. Each year Swim Across America Nantucket is proud to host more than 400 swimmers and volunteers, spectators and supporters, as well as Olympians near and far at the charity swim. This year’s swim will take place on Saturday July 22, 2023, at Jetties Beach on the island of Nantucket.

Promising CAR T-cell Therapy for Ependymoma Funded by Swim Across America-Boston Launches Phase I Study

Posted on April 19, 2023 Posted in Uncategorized1 Comment

With early funding from Swim Across America-Boston, Dr. Bryan Choi’s research on tandem CAR T-cell therapy for ependymoma has been approved for a Phase I trial. The first human patient will be infused at the end of April 2023.

Dr. Choi, a neurosurgeon and neuro-oncologist at Massachusetts General Hospital, presented an overview of his research path in an exclusive briefing to Swim Across America participants on Friday, April 14, 2023. He explained that he is particularly interested in finding nonsurgical, nonconventional means of treating solid tumor cancers like ependymoma, an aggressive solid tumor brain cancer that occurs most often in young children.

CAR T-cell therapy, a type of gene therapy that engineers a patient’s own T-cells (a type of white blood cells) to identify and attack cancer cells by way of their antigen markers, has shown promise in the treatment of blood cancers. The research team created dual antigen-targeting tandem CAR T (TanCART) cells to target heterogeneous solid tumors. Dr. Choi’s research shows that this type of therapy can also be manipulated to treat solid tumors like ependymoma.

At the suggestion of Dr. Howard Weinstein, Unit Chief of Pediatric Hematology/Oncology at Mass General for Children and long-time Swim Across America partner, Dr. Choi applied for a Swim Across America research grant through the internal competitive bid program at Mass General for Children.

Through Dr. Choi’s research, CAR T-cell therapy is now showing promise in treating solid tumor cancers like ependymoma – so much promise that it has been approved for a Phase I trial in human patients.

Without the Swim Across America grant, Dr. Choi said, his research likely would have remained unfunded, and neither the FDA approval nor the Phase I Study approval, which is funded by industry investors, would have been possible.

Janel Jorgensen McArdle, Chief Operating Officer of Swim Across America, pointed out that Dr. Choi’s research falls in the “sweet spot” of the high risk, high reward research that Swim Across America is pursuing. “This promising research aligned perfectly with the opportunities that Swim Across America seeks to support. We are so excited that SAA funding could help accelerate it to patient trials.”

After his highly informative presentation, Dr. Choi and his lab colleagues gave us a private tour of their existing lab spaces, as well as their new expanded lab, which is in the finishing stages of build-out.

It was an exciting visit for Swim Across America news and for all of the Swim Across America-Boston and Nantucket supporters who were present!

Swim Across America visitors: Michele Fox, Patty Gienke, Bob Hackett, Liam Hackett, Steven Laduzinski, Jamie Mannion, Janel Jorgensen McArdle, Alex Meyer, Rick Osterberg, Shep Perkins, Jill Roethke, Mike Ryan, Jessica Stokes, Kitty Tetreault.

SWIM ACROSS AMERICA – FLORIDA KEYS IN THE NEWS

Posted on April 18, 2023April 19, 2023 Posted in #DefeatCancer, Events, Family Tree, Fundraising, Labs, News, olympians, UncategorizedTagged cancer, media, News, olympians, swim across america, televisionLeave a comment

Read or watch local stories featuring the Swim Across America-Florida Keys community to learn about their impact. Learn more about the event and beneficiary, Miami Cancer Institute, at swimacrossamerica.org/floridakeys.

SWIM ACROSS AMERICA – NASHVILLE IN THE NEWS

Read or watch local stories featuring the Swim Across America-Nashville community to learn about their impact. Learn more about the event and beneficiary, Vanderbilt-Ingram Cancer Center, at swimacrossamerica.org/nashville.

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April 16 Swim Across America Nashville Makes Waves to Fight Cancer

Finding New Meaning in Swim Across America Participation

Posted on April 5, 2023 Posted in #DefeatCancer, #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, event directors, UncategorizedTagged cancer, cancer research, fundraise, swim across america1 Comment

Susan McPherson

Swim Across America – Nashville

Hometown: Nashville, Tennessee

6 years with Swim Across America

Age: 79

Susan McPherson was no stranger to Swim Across America, but her contributions were always in honor of other family members and friends who had cancer diagnoses. After a shocking diagnosis in December 2020, the reason to support Swim Across America-Nashville now became much more personal for Susan.

“I went to the doctor because I was experiencing new-onset shortness of breath and found out I was anemic. After additional tests, the doctors told me they found a large tumor and multiple metastases in my abdomen and that I had stage four colon cancer.”

Susan’s particular genetic profile made her a candidate for immunotherapy. She began treatment at the Vanderbilt-Ingram Cancer Center, which is the beneficiary of the Swim Across America-Nashville Pool Swim.

“In fact, the type of immunotherapy I was given – Keytruda – was developed in the Swim Across America funded lab at the Johns Hopkins Cancer Center! What an incredibly serendipitous moment it was when I realized that the treatment that could help save my life was initially funded through Swim Across America fundraising events.”

Susan received treatment for two years and is now cancer-free. And her participation in this year’s Swim Across America – Nashville event is that much more poignant.

Susan’s daughter-in-law, Chris, is one of the event directors and coaches at the Ensworth Natatorium where the event is held. Her son, John, is a cardiologist at Vanderbilt University Medical Center. For the second year, Chris and John will swim with their team “Chris’ Cancer Crushers” in their endeavor to “make waves to fight cancer.”

Swim Across America has raised $100 million since its inception in 1987 to support cancer research and clinical trials across the U.S. Please contact Jeni Howard at jhoward@jhowardpr.com for media inquiries.

Young Teen Recognizes Swim Across America’s Impact Within His Home

Posted on April 5, 2023June 26, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, Uncategorized, wave makerTagged cancer, cancer research, fundraise, swim across america1 Comment

Owen Johnson

Swim Across America – Charleston-Kiawah

Hometown: Mount Pleasant, South Carolina

3 years supporting Swim Across America

Age: 13

Owen Johnson is just 13 years old, and he already recognizes the impact funds raised at a Swim Across America charity swim have on patients and families.

“My dad, Brad Johnson, was diagnosed with stage four head and neck cancer before I was born. He survived because of new medicines discovered by cancer researchers, like the ones funded by Swim Across America.”

In 2020, the then-11-year-old swimmer had the idea to give his dad an unforgettable Christmas present. Instead of exchanging gifts, Owen set up a GoFundMe in honor of his dad’s fight against cancer. Owen raised over $2,000 and since then, has raised another $4,000 through his participation in the Swim Across America – Charleston-Kiawah events.

“I know Swim Across America gives money directly to researchers. My dad was the Event Director for Swim Across America – Charleston-Kiawah for a few years, and Swim Across America gives grants to cancer researchers at Hollings Cancer Center in Charleston where we live.”

This year, Owen and Brad will swim together at the Swim Across America – Charleston-Kiawah event on June 10. They are also celebrating a remarkable milestone. Brad has been cancer-free for 20 years.

“To celebrate 20 years and all the things my dad has accomplished since beating cancer – Ironman events, marathons, Triathlon World Championships, having a family – we are teaming up to raise $20,000 for the 2023 Swim Across America – Charleston-Kiawah event.”

“I hope that by raising money for Swim Across America, donations will help researchers get the funding they need to help more people like my dad.”

Cancer Survivor Inspired to Help Establish SAA-Florida Keys Event

Posted on April 4, 2023 Posted in #MakingWavesToFightCancer, event directors, UncategorizedTagged cancer, cancer research, fundraise, swim across americaLeave a comment

Glenn Latham

Swim Across America – Florida Keys

Hometown: Islamorada, Florida

2 years supporting Swim Across America

Age: 68

“Both my parents, two of my three siblings, and I have all battled cancer. Fortunately, due to lots of prayer, family support and modern technology, I am in remission and celebrating 11 years cancer-free.”

And thanks to a chance meeting with a Swim Across America Board Member, Glenn and his wife, Susan, are now dedicated to bringing hope to families fighting cancer.

As a cancer survivor, Glenn was involved with different charities prior to moving to the Keys. Glenn’s love of swimming led to that chance encounter with a Board Member who shared the story of Swim Across America and our mission to fund innovative cancer research.

“My wife and I were immediately interested, and together we decided to organize the first SAA event in the Florida Keys. Our inaugural event in 2022 was a huge success, and the community involvement was amazing.”

The two Islamorada residents are Co-Event Directors for the second annual Swim Across America – Florida Keys event on April 15 benefitting Miami Cancer Institute.

“Being involved with Swim Across America has been a wonderful experience. I hope to continue to help with our own event and attend other swims. I believe we need to expand cancer research, and the funding that Swim Across America generates is of huge value.”

“It is particularly gratifying meeting and working with key members of the local medical research institution, Swim Across America staff, Olympians and local community supporters.”

SAA Debuts WaveMaker Hydro Flask Bottle for 2023

Posted on March 22, 2023March 22, 2023 Posted in #DefeatCancer, Corporate Partners, Fundraising, Uncategorized, wave makerTagged backpack, buttons, fundraise, merchandise, swag, swim across america, WaveMakerLeave a comment

Swim Across America is excited to celebrate our top fundraisers with the 2023 WaveMaker gift! Swimmers and volunteers who raise $1,000 or more will receive an insulated 32 oz Wide-Mouth Hydro Flask water bottle.

As part of the WaveMaker club, we want you to show your SAA pride year-round with a Hydro Flask perfect for any occasion. Ideal for everyday and outdoor adventure, the Hydro Flask Wide-Mouth vacuum water bottle packs 32 oz. of hydration, and keeps your beverage hot or cold for hours. Want to take this awesome item home with you? Register today and set your fundraising goal to WaveMaker!

FDA Advisory Committee Supports Expanding Clinical Trial Swim Across America Has Helped Fund

Posted on February 21, 2023 Posted in #MakingWavesToFightCancer, #SwimAcrossAmerica, beneficiaries, Grant, Labs, UncategorizedLeave a comment

An immunotherapy clinical trial that Swim Across America provided grant funding has reached another milestone.

The Dr. Luis Diaz Lab at Memorial Sloan Kettering began receiving grants from Swim Across America in 2017. SAA grant funding allowed Dr. Diaz and his colleague, Dr. Andrea Cercek, to meet patients and conduct immunotherapy research. With SAA grant support, the lab opened a clinical trial and recruited 14 patients with advanced rectal cancer. The patients qualified through genetic testing and were treated with a single dose of immunotherapy. The patients didn’t require surgery, chemo, or radiation–which was remarkable as traditional treatments often have a negative emotional, physical, and financial effect on the quality of life for patients and their families.

Dr. Luis Diaz and Dr. Andrea Cercek

All 14 patients responded with no evidence of disease. This is believed to be the first time a clinical trial has shown a 100% response rate. Read the full story here.

Recently, the FDA Advisory Committee supported expanding the clinical trial to more patients based on the data from the trial.

The Diaz/Cercek lab has focused on rectal cancer where standard treatment options are surgery, chemotherapy, and radiation. While these treatments might save a patient, they have significant quality-of-life effects and often present the need for ongoing care.

This trial is genetically dependent and focused on advanced rectal cancer. Dr. Diaz and Dr. Cercek envision the immunotherapy being offered to patients with other cancer types who meet the genetic profile. Proceeds from the Long Island Sound and Nassau/Suffolk – Sound to Cove charity swims continue to help fund the ongoing research and clinical trial at Memorial Sloan Kettering.

Swim Across America has a proven track record of identifying and funding early-stage ideas of promise. Swim Across America grants have played a major role in clinically developing FDA-approved immunotherapy treatments ipilimumab (YERVOY), nivolumab (OPDIVO), pembrolizumab (KEYTRUDA), and atezolizumab (TECENTRIQ).

MORE THAN $300,000 IN ACTIVE GRANTS AT LEVINE CANCER INSTITUTE FROM SWIM ACROSS AMERICA

Posted on February 14, 2023 Posted in UncategorizedTagged cancer, cancer research, charlotte, Levine Cancer Institute, North Carolina, swim across americaLeave a comment

With grant support from Swim Across America–Charlotte, researchers at Levine Cancer Institute and Levine Children’s Hospital aim to make progress with the following projects. Since 2017, Swim Across America–Charlotte has awarded more than $750,000 to fund research and education programs at LCI.

Grant Recipient: Greg Knight, M.D.

Project: How Distress and Psychologic Well-Being Affect Outcomes for Patients with Hematologic Malignancies

As the science of cancer treatment in the United States continues to accelerate and treatment becomes more personalized (and expensive), barriers to the implementation of optimal cancer care have been increasingly recognized as major determinants of outcomes. Evidence is emerging that psychosocial stress is impacting care. Such data have led to almost all major professional oncologic organizations, including ASCO, NCCN, and American College of Surgeons’ Commission on Cancer, recommending screening for stress as part of routine care. With funding from Swim Across America, Dr. Knight is leading a first of its kind study, exploring the impact of stress in hematologic malignancies, and examine how to alleviate these stressors to improve the outcomes for these patients.

Grant Recipients: Srinivasa Sanikommu, M.D.; Lawrence Druhan, Ph.D.

Project: Effects of Vitamin C in Patients with Leukemia and Myelodysplasia

Vitamin C has long been postulated to have beneficial/and preventative effects in many diseases, but whether and/or how vitamin helps patients with blood cancers is unknown. We have seen in the laboratory that when vitamin C is added to some chemotherapy agents, there is inhibition of cancer cell growth. Thus, if vitamin C is deficient in some patients, it is possible that responses to therapy could be improved by addition of vitamin C. With funding from Swim Across America, Drs. Sanikommu and Druhan are studying how the addition of Vitamin C could improve the outcomes for patients with leukemia and blood cancers, and potentially even prevent the development of these diseases.

Grant Recipient: Brittany Ragon, M.D

Project: Personalized Medicine for the Treatment of Leukemia

In leukemia care, the choice and dosing of therapy can be an empiric exercise; there are increasing data showing that best therapies and best dosing can be predicted using genetics. A new drug called venetoclax (ven) is now part of the standard treatment for upfront treatment in many patients with acute myeloid leukemia (AML). Despite improvements in outcomes for AML patients with venetoclax, the real-world usage of ven is complex, and toxicities leading to dose modifications are common. Using funding from Swim Across America, Dr. Ragon is leading an innovative study to explore candidate gene changes as predictors of response to ventoclax-containing regimens to develop a personalized approach to patient care.

Grant Recipient: Yifan Pang, M.D.

Project: Immune System Functional Monitoring to Improve Hematopoietic Stem Cell Transplant

Hematopoietic stem cell transplant (HSCT) can be the cure for many blood diseases. Including adults and children, more than 8,000 HSCTs are performed in the U.S. annually and more than 50,000 world-wide. The success of HSCT is dependent on the reconstitution of the immune system from transplanted cells, which is responsible for controlling infections, preventing transplant rejection, and prevention of disease recurrence. Current methods to monitor immune reconstitution are not good at measuring the global health of the immune system. Therefore, it is critical to identify a reliable marker to comprehensively measure post-HSCT immune reconstitution to prevent complications and improve outcomes. With funding from Swim Across America, Dr. Yifan Pang will lead a project aimed at the development of a novel method to measure immune reconstitution after HSCT using cutting-edge next generation sequences methods.

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